A Difunctional Regeneration Scaffold for Knee Repair based on Aptamer‐Directed Cell Recruitment. Issue 15 (10th February 2017)

• Record Type: Journal Article
• Authors: Hu, Xiaoxia; Wang, Yulan; Tan, Yaning; Wang, Jie; Liu, Haoyang; Wang, Yingqian; Yang, Shuang; Shi, Miusi; Zhao, Shiyong; Zhang, Yufeng; Yuan, Quan
• Is Part Of: Advanced materials. Volume 29:Issue 15(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-10
• Subjects: aptamers -- cell recruitment -- knee repair -- osteochondral defect -- scaffolds; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201605235
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : To solve the challenge of poor knee repair, an aptamer‐bilayer scaffold is designed for autologous mesenchymal stem cell (MSC) recruitment and osteochondral regeneration. The scaffold can efficiently recruit MSCs to the defect and induce the directional differentiation of MSCs, thus successfully achieving simultaneous regeneration of cartilage and bone in the knee joint.