Photoacoustic‐Enabled Self‐Guidance in Magnetic‐Hyperthermia Fe@Fe3O4 Nanoparticles for Theranostics In Vivo. Issue 9 (22nd January 2018)

• Record Type: Journal Article
• Authors: Zhou, Ping; Zhao, Heng; Wang, Quan; Zhou, Zhiguo; Wang, Jing; Deng, Guang; Wang, Xiyou; Liu, Qian; Yang, Hong; Yang, Shiping
• Is Part Of: Advanced healthcare materials. Volume 7:Issue 9(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-01-22
• Subjects: Fe@Fe3O4 nanoparticles -- in vivo theranostics -- magnetic hyperthermia -- PA imaging; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201701201
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Magnetic nanoparticles have gained much interest for theranostics benefited from their intrinsic integration of imaging and therapeutic abilities. Herein, c(RGDyK) peptide PEGylated Fe@Fe3 O4 nanoparticles (RGD‐PEG‐MNPs) are developed for photoacoustic (PA)‐enabled self‐guidance in tumor‐targeting magnetic hyperthermia therapy in vivo. In the αv β3 ‐positive U87MG glioblastoma xenograft model, the PA signal of RGD‐PEG‐MNPs reaches its maximum in the tumor at 6 h after intravenous administration. This signal is enhanced by 2.2‐folds compared to that of the preinjection and is also 2.2 times higher than that in the blocking group. It demonstrates the excellent targeting property of RGD‐PEG‐MNPs. With the guidance of the PA, an effective magnetic hyperthermia to tumor is achieved using RGD‐PEG‐MNPs. Abstract : A single material‐based nanotheranostic agent of c(RGDyK) peptide PEGylated Fe@Fe3 O4 nanoparticles is developed for targeting photoacoustic imaging guided magnetic hyperthermia therapy in the αv β3 ‐positive U87MG glioblastoma xenograft model.