Frontispiece: Triphenylphosphine‐Mediated Deoxygenative Reduction of CF3SO2Na and Its Application for Trifluoromethylthiolation of Aryl Iodides. Issue 3 (8th January 2016)

• Record Type: Journal Article
• Authors: Yang, Yi; Xu, Long; Yu, Siqi; Liu, Xiaoqiang; Zhang, Yu; Vicic, David A.
• Is Part Of: Chemistry. Volume 22:Issue 3(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-01-08
• Subjects: copper -- cross-coupling -- fluorine -- organic chemistry -- sulfur; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201680361
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Versatility of Langlois′ Reagent A simple and cost‐effective method towards taming Langlois′ reagent for the synthesis of copper trifluoromethylthiolate complexes has been established. This chemistry highlights a novel liberation of the inherent CF3 S skeleton of Langlois′ reagent under mild deoxygenative reduction conditions. The CuSCF3 intermediate prepared this way can be used to generate several air‐stable [LCu(SCF3 )] complexes as valuable trifluoromethylthiolating agents. Additionally, the CuSCF3 intermediate can be directly employed for the trifluoromethylthiolation of (hetero)aryl iodides with operational simplicity and atomic efficiency. For more details, see the Communication by Y. Yang, D. A. Vicic et al. onpage 858 ff.