Coordination Polymers Derived from Non‐Steroidal Anti‐Inflammatory Drugs for Cell Imaging and Drug Delivery. Issue 3 (11th December 2015)

• Record Type: Journal Article
• Authors: Paul, Mithun; Dastidar, Parthasarathi
• Is Part Of: Chemistry. Volume 22:Issue 3(2016)
• Page Start: 988
• Page End: 998
• Publication Date: 2015-12-11
• Subjects: biocompatibility -- cell imaging -- coordination polymers -- drug delivery -- photoluminescence; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201503706
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A new series of Mn II coordination polymers, namely, [{Mn(L)(H2 O)2 }⋅ 2 Nap]∞ (CP1 ), [{Mn(L)(Ibu)2 (H2 O)2 }]∞ (CP2 ), [{Mn(L)(Flr)2 (H2 O)2 }]∞ (CP3 ), [{Mn(L)(Ind)2 (H2 O)2 }⋅ H2 O]∞ (CP4 ), [{Mn2 (L)2 (μ‐Flu)4 (H2 O)}⋅ L]∞ (CP5 ), [{Mn2 (L)2 (μ‐Tol)4 (H2 O)2 }]∞ (CP6) and [{Mn2 (L)2 (μ‐Mef)4 (H2 O)2 }]∞ (CP7 ) (Nap=naproxen, Ibu=ibuprofen, Flr=flurbiprofen, Ind=indometacin, Flu=flufenamic acid, Tol=tolfenamic acid and Mef=mefenamic acid) derived from various non‐steroidal anti‐inflammatory drugs (NSAIDs) and the organic linker 1, 2‐bis(4‐pyridyl)ethylene (L) have been synthesized with the aim of being used for cell imaging and drug delivery. Single‐crystal X‐ray diffraction (SXRD) studies revealed that the NSAID molecules were part of the coordination polymeric network either through coordination to the metal center (in the majority of the cases) or through hydrogen bonding. Remarkably, all the Mn II coordination polymers were found to be soluble in DMSO, thereby making them particularly suitable for the desired biological applications. Two of the coordination polymers (namely, CP1 andCP3 ) reported herein, were found to be photoluminescent both in the solid as well as in the solution state. Subsequent experiments (namely, MTT (3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide), and PGE2 (prostaglandin E2 ) assays) established their biocompatibility and anti‐inflammatory response. In vitro studies by using a macrophage cell line (i.e., RAW 264.7) revealed that bothCP1 andCP3 were excellent cell imaging agents. Finally, biodegradability studies under simulated physiological conditions in phosphate‐buffered saline (PBS) at pH 7.6 showed that slow and sustained release of the corresponding NSAID was indeed possible from bothCP1 andCP3 . Abstract : Coordinated functions : A series of Mn II ‐based coordination polymers was derived from different non‐steroidal anti‐inflammatory drugs (NSAIDs), which showed excellent cell imaging, in vitro anti‐inflammatory, and drugdelivery properties (see figure).