Cover Feature: Biocatalytic Synthesis of Nitriles through Dehydration of Aldoximes: The Substrate Scope of Aldoxime Dehydratases (ChemBioChem 8/2018). (23rd March 2018)

• Record Type: Journal Article
• Authors: Betke, Tobias; Higuchi, Jun; Rommelmann, Philipp; Oike, Keiko; Nomura, Taiji; Kato, Yasuo; Asano, Yasuhisa; Gröger, Harald
• Is Part Of: Chembiochem. Volume 19:Number 8(2018)
• Page Start: 766
• Page End: 766
• Publication Date: 2018-03-23
• Subjects: aldoxime dehydratases -- biocatalysis -- enzyme catalysis -- nitriles -- stereochemistry; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201800139
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The cover feature picture shows the product diversity of a recently developed enzymatic approach towards nitriles based on the use of aldoxime dehydratases, which catalyse the dehydration of aldoximes as readily available substrates. This biocatalytic methodology represents an alternative, cyanide‐free route towards the product class of nitriles, which are widely used in the chemical industry. The enzyme properties and the substrate scope of this enzymatic transformation, which covers aliphatic, aromatic and arylaliphatic aldoximes as well as aldoxime substrates bearing a stereogenic center, are described in the Minireview by Y. Asano, H. Gröger et al. onpage 768 in Issue 8, 2018 (DOI:10.1002/cbic.201700571 ).