Cytotoxicity of Postmodified Zeolitic Imidazolate Framework‐90 (ZIF‐90) Nanocrystals: Correlation between Functionality and Toxicity. Issue 9 (28th January 2016)

• Record Type: Journal Article
• Authors: Yen, Chia‐I; Liu, Szu‐Mam; Lo, Wei‐Shang; Wu, Jhe‐Wei; Liu, Yi‐Hsin; Chein, Rong‐Jie; Yang, Renqiang; Wu, Kevin C.‐W.; Hwu, Jih Ru; Ma, Nianhan; Shieh, Fa‐Kuen
• Is Part Of: Chemistry. Volume 22:Issue 9(2016)
• Page Start: 2925
• Page End: 2929
• Publication Date: 2016-01-28
• Subjects: cytotoxicity -- drug carriers -- metal–organic frameworks -- post-modification -- ZIF-90; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201505005
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Using a simple method, the aldehyde groups of zeolitic imidazolate framework‐90 (ZIF‐90) nanocrystals were converted into carboxyl, amino, and thiol groups, without affecting the integrity of the framework. Notably, for the first time, correlations between functionality and cytotoxicity are also demonstrated via in vitro cytotoxicity assays. The positive charged aminated‐ZIF‐90 presumably results in either perturbation of cell membrane, more efficient cell uptake, or both. Therefore, the half‐maximal effective (EC50 ) concentration of aminated‐ZIF‐90 has a higher cytotoxicity of about 30 μg mL −1 . Abstract : Supermodification : ZIF‐90 (zeolitic imidazolate framework‐90) nanocrystals were substituted with carboxyl, amino, and thiol groups without affecting framework integrity. In vitro cytotoxicity assays reveals that the positively charged aminated ZIF‐90 presumably results in perturbation of cell membrane and/or more efficient cell uptake. The half‐maximal effective (EC50 ) concentration of aminated‐ZIF‐90 has a higher cytotoxicity (ca. 30 μg mL −1 ).