Current and future perspectives in the management of gastroesophageal reflux disease. Issue 1 (16th May 2018)

• Record Type: Journal Article
• Authors: Akiyama, Junichi; Kuribayashi, Shiko; Baeg, Myong Ki; de Bortoli, Nicola; Valitova, Elen; Savarino, Edoardo V.; Kusano, Motoyasu; Triadafilopoulos, George
• Other Names: Giuli Robert guestEditor.
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1434:Issue 1(2018)
• Page Start: 70
• Page End: 83
• Publication Date: 2018-05-16
• Subjects: gastroesophageal reflux disease -- functional gastrointestinal disorders -- nocturnal reflux -- aspiration -- refractory; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.13850
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract: Although the prevalence of gastroesophageal reflux disease (GERD) used to be lower in East Asia as compared to Western countries, it has recently been increasing, most likely due to the socioeconomic development in the East. The prevalence of both GERD and functional gastrointestinal disorders (FGIDs) ranges between 10% and 25% worldwide and there are distinct subgroups of patients with overlapping of GERD and FGIDs. However, the true prevalence of an overlap between GERD and FGIDs can be determined only when a formal pathophysiological evaluation has been performed. Nocturnal reflux symptoms have a significant impact on patients' sleep quality and quality of life. Although proton pump inhibitors (PPIs) can improve both reflux and sleep‐related symptoms, the relationship between nocturnal reflux events and sleep disturbance is not fully understood. GERD plays an important role in the pathogenesis of lung fibrosis, and PPIs or fundoplication may decrease the likelihood of pulmonary exacerbation or even improve pulmonary function. Refractory reflux symptoms without esophagitis have become one of the most common presentations of GERD in gastroenterology clinics. There are several new medical therapies, and endoscopic as well as laparoscopic techniques that have been increasingly used in these patients. The selection of options should be tailored and individualized based on the pathophysiology of refractory GERD. Abstract : Gastroesophageal reflux disease (GERD) is a condition, which develops when the reflux of stomach contents causes troublesome symptoms and/or complications. The prevalence of GERD varies remarkably throughout the world, the causes of GERD symptoms are likely multifactorial and its pathophysiology is not fully understood. In this concise review, we have reviewed current and future perspectives in the management of GERD.