Role of oxidative stress, infection and inflammation in male infertility. (20th December 2018)

• Record Type: Journal Article
• Authors: Agarwal, Ashok; Rana, Mohit; Qiu, Emily; AlBunni, Hashem; Bui, Albert D.; Henkel, Ralf
• Other Names: Lustig Livia guestEditor.; Allam Jean‐Pierre guestEditor.
• Is Part Of: Andrologia. Volume 50:Number 11(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-12-20
• Subjects: causes of oxidative stress -- male genital tract infections -- oxidative stress -- sexually transmitted diseases; Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.13126
• Languages: English
• ISSNs: 0303-4569

Abstract

Abstract: Oxidative stress (OS), defined as an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, has been linked to sperm damage and male infertility. There are many sources of OS and inflammation including varicocele, tobacco usage, alcohol, obesity/metabolic syndrome, leukocytospermia, sexually transmitted disease (i.e., Neisseria gonorrhoeae, Chlamydia trachomatis, Treponema pallidum), bacterial prostatitis, microorganism mutations leading to more OS, and viral infections (i.e., human immunodeficiency virus, hepatitis). This review is focusing on infection and inflammation‐mediated OS, the inflammatory markers underlying pathology, clinical significance in male infertility, and a brief description of the recommended treatment modalities.