Allelic variation in dopamine D2 receptor gene is associated with attentional impulsiveness on the Barratt Impulsiveness Scale (BIS-11). (31st October 2018)

• Record Type: Journal Article
• Authors: Taylor, Jasmine B.; Cummins, Tarrant D. R.; Fox, Allison M.; Johnson, Beth P.; Tong, Janette H.; Visser, Troy A. W.; Hawi, Ziarih; Bellgrove, Mark A.
• Is Part Of: World journal of biological psychiatry. Volume 19(2018)Supplement 2
• Page Start: S75
• Page End: S83
• Publication Date: 2018-10-31
• Subjects: DRD2 -- catecholamine -- attention -- impulsivity -- BIS; Biological psychiatry -- Periodicals; Biological Psychiatry -- Periodicals; 616.89
• DOI: 10.1080/15622975.2016.1273549
• Languages: English
• ISSNs: 1562-2975

Abstract

Abstract: Objectives: Previous studies have postulated that noradrenergic and/or dopaminergic gene variations are likely to underlie individual differences in impulsiveness, however, few have shown this. The current study examined the relationship between catecholamine gene variants and self-reported impulsivity, as measured by the Barratt Impulsiveness Scale (Version 11; BIS-11) Methods: Six hundred and seventy-seven non-clinical adults completed the Barratt Impulsiveness Scale (BIS-11). DNA was analysed for a set of 142 single-nucleotide polymorphisms (SNPs) across 20 autosomal catecholamine genes. Association was tested using an additive regression model with permutation testing used to control for the influence of multiple comparison. Results: Analysis revealed an influence of rs4245146 of the dopamine D2 receptor (DRD2) gene on the BIS-11 attention first-order factor, such that self-reported attentional impulsiveness increased in an additive fashion with each copy of the T allele. Conclusions: These findings provide preliminary evidence that allelic variation in DRD2 may influence impulsiveness by increasing the propensity for attentional lapses.