The study on the cell survival for bioartificial liver by using standardisation extracorporeal circulation method. (2017)

• Record Type: Journal Article
• Authors: Kim, Seonghwan; Cheon, Minwoo
• Is Part Of: International journal of advanced media and communication. Volume 7:Number 3(2017)
• Page Start: 197
• Page End: 204
• Publication Date: 2017
• Subjects: extracorporeal circulation -- standardisation -- plasma perfusion -- artificial organ -- cell survival -- artificial -- bioreactor; Multimedia communications -- Periodicals; Multimedia systems -- Periodicals; 384.38
• Languages: English
• ISSNs: 1462-4613

Abstract

This research is on the standardisation of perfusion to help increase the survival rate of hepatic insufficiency patients through the enhanced cell survival of artificial livers. Generally, artificial livers are used in the form of extracorporeal circulation with a mounted bioreactor. As artificial livers need to replace liver functions, to enhance the liver cell survival ratio in the bioreactor, the bioreactor performance needs to be improved. To this end, perfusion standardisation is required in the extracorporeal circulation and each circulation pumps should be interoperable. In this study looked at possible standardisation of perfusion methods capable of increasing liver cell survival rate in order to find out the optimal standardised bioreactor. As a result, perfusion 2 control was found to be essential in raising the cell survival ratio and perfusion 3 implementation enhanced the survival ratio.