Prevalence of nasopharyngeal pneumococcal colonization in children and antimicrobial susceptibility profiles of carriage isolates. (October 2015)

• Record Type: Journal Article
• Authors: Zhou, Julie Y.; Isaacson-Schmid, Megan; Utterson, Elizabeth C.; Todd, Elizabeth M.; McFarland, Michelle; Sivapalan, Janardan; Niehoff, Joan M.; Burnham, Carey-Ann D.; Morley, S. Celeste
• Is Part Of: International journal of infectious diseases. Volume 39(2015:Oct.)
• Page Start: 50
• Page End: 52
• Publication Date: 2015-10
• Subjects: Streptococcus pneumoniae -- colonization -- epidemiology -- antimicrobial resistance; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2015.08.010
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: The prevalence of pneumococcal colonization in a pediatric population in the USA is 34%. The 13-valent pneumococcal conjugate vaccine (PCV13) did not alter prevalence. PCV13 did not increase the prevalence of penicillin-susceptible isolates. Summary: Nasopharyngeal (NP) pneumococcal carriage predisposes children to pneumococcal infections. Defining the proportion of pneumococcal isolates that are antibiotic-resistant enables the appropriate choice of empiric therapies. The antibiogram of NP carriage isolates derived from a pediatric population following the introduction of the 13-valent pneumococcal conjugate vaccine was defined in this study.