Infection and inflammatory mechanisms. Issue 4 (1st April 2013)

• Record Type: Journal Article
• Authors: Van Dyke, Thomas E.; van Winkelhoff, Arie Jan
• Is Part Of: Journal of periodontology. Volume 84:Issue 4(2013)Supplement 1
• Page Start: S1
• Page End: S7
• Publication Date: 2013-04-01
• Subjects: cardiovascular disease -- infection -- inflammation -- pathogenesis -- periodontitis -- systemic diseases; Periodontics -- Periodicals; 617.632
• DOI: 10.1902/jop.2013.1340018
• Languages: English
• ISSNs: 0022-3492

Abstract

Abstract: This introductory article examines the potential mechanisms that may play a role in the associations between periodontitis and the systemic conditions being considered in the EFP/AAP Workshop in Segovia, Spain. Three basic mechanisms have been postulated to play a role in these interactions; metastatic infections, inflammation and inflammatory injury, and adaptive immunity. The potential role of each alone and together is considered in in vitro and animal studies and in human studies when available. This is not a systematic or critical review, but rather an overview of the field to set the stage for the critical reviews in each of the working groups.