Immunogenicity of sequential inactivated and oral poliovirus vaccines (OPV) versus inactivated poliovirus vaccine (IPV) alone in healthy infants: A systematic review and meta-analysis. Issue 11 (2nd November 2018)

• Record Type: Journal Article
• Authors: Tang, Guihua; Yin, Wen; Cao, Youde; Tan, Liming; Wu, Shuyu; Cao, Yudong; Fu, Xianyong; Yan, Jing; Jiang, Xingjun
• Is Part Of: Human vaccines & immunotherapeutics. Volume 14:Issue 11(2018)
• Page Start: 2636
• Page End: 2643
• Publication Date: 2018-11-02
• Subjects: Inactivated poliovirus vaccines -- Oral poliovirus vaccines -- Immunogenicity -- sequential schedule -- vaccination; Vaccines -- Periodicals; 615.372
• DOI: 10.1080/21645515.2018.1489188
• Languages: English
• ISSNs: 2164-5515

Abstract

ABSTRACT: Background: The emergence of vaccine-associated paralytic poliomyelitis has become an ongoing burden of poliomyelitis. During this special period from OPV to IPV-only immunization schedule, we did a meta-analysis to compare the immunogenicity of sequential IPV and OPV versus IPV alone in healthy infants. Methods: This systematic review and meta-analysis was registered at international prospective register of systematic reviews (PROSPERO), and the number was CRD42017054889. We performed it as described. Results: Finally, 6 articles were qualified for our review. The results showed that seroconversion rates against all 3 serotype polioviruses were non-inferior and Geometric mean antibody titers (GMTs) were superior in sequential schedules compared with IPV-only schedule. Thus, the sequential vaccination schedules could induce a stronger immunogenicity. Conclusions: To decrease vaccine-associated and vaccine-derived poliomyelitis, it is a reasonable option to select sequential schedules during this special transition from OPV to IPV-only immunization schedule, which coincides with the current WHO recommendations.