Lithium-containing biomaterials inhibit osteoclastogenesis of macrophages in vitro and osteolysis in vivo. Issue 48 (21st November 2018)

• Record Type: Journal Article
• Authors: Pan, Chenhao; Chen, Lei; Wu, Ruoyu; Shan, Haojie; Zhou, Zubin; Lin, Yiwei; Yu, Xiaowei; Yan, Liang; Wu, Chengtie
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 48(2018)
• Page Start: 8115
• Page End: 8126
• Publication Date: 2018-11-21
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb02678e
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Li-containing bioceramics were promising biomaterials for inhibiting osteoclastogenesis of macrophages and osteolysis in vivo, potentially using for treating osteoporosis. Abstract : Osteolysis, which is caused by aging, neoplasia, infection, or trauma, is a type of intractable systemic or local syndrome of bone destruction ( e.g., peri-implant osteolysis (PIO)). The activation of osteoclasts differentiated from macrophages plays a decisive role in such diseases. To conquer this challenge, herein, a biomaterial capable of inhibiting osteoclastogenesis and osteolysis was designed. Recent research has shown that lithium (Li) can inhibit pro-inflammatory cytokine release in vitro via affecting the pharmacotherapy of psychiatric illnesses. Therefore, we synthesized a pure-phase lithium–calcium–silicate (Li2 Ca2 Si2 O7, LCS) bioceramic and further prepared extracts to assess the effect of LCS on RANKL-induced osteoclastogenesis in vitro and Ti particle-induced osteolysis in vivo as well as the corresponding mechanism. The results demonstrated that LCS inhibited RANKL-induced osteoclastogenesis of macrophages, bone resorption area, and F-actin ring formation in a dose-dependent manner. The mechanism is related to the suppression of the NF-kB signaling pathways mediating the inhibitory effects of LCS. Moreover, LCS was found to be able to inhibit calvarial osteolysis in a mouse model through micro-CT and histological analysis. These findings suggest that LCS may be a promising biomaterial for suppressing osteolysis, thus paving the way for the treatment of osteoporosis using bioactive inorganic materials.