Direct synthesis of 3-acylbenzothiophenes via the radical cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids. Issue 100 (3rd December 2018)

• Record Type: Journal Article
• Authors: Liu, Wei; Hu, Yao-Qian; Hong, Xiao-Yi; Li, Guo-Xing; Huang, Xiao-Bo; Gao, Wen-Xia; Liu, Miao-Chang; Xia, Yuanzhi; Zhou, Yun-Bing; Wu, Hua-Yue
• Is Part Of: Chemical communications. Volume 54:Issue 100(2018)
• Page Start: 14148
• Page End: 14151
• Publication Date: 2018-12-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc07735e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A radical cascade cyclization strategy has been developed to provide a direct route to access 3-acylbenzothiophenes from simple chemical feedstocks. Abstract : A radical cascade cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids with AgNO3 has been described. This reaction provides a novel route to directly access 3-acylbenzothiophenes from simple chemical feedstocks. In particular, the utility of the approach was demonstrated by its application to the synthesis of a polymerization inhibitor and a raloxifene precursor.