A β-glucuronidase-responsive albumin-binding prodrug programmed for the double release of monomethyl auristatin E. Issue 12 (15th November 2018)
- Record Type:
- Journal Article
- Title:
- A β-glucuronidase-responsive albumin-binding prodrug programmed for the double release of monomethyl auristatin E. Issue 12 (15th November 2018)
- Main Title:
- A β-glucuronidase-responsive albumin-binding prodrug programmed for the double release of monomethyl auristatin E
- Authors:
- Renoux, Brigitte
Fangous, Laure
Hötten, Camille
Péraudeau, Elodie
Eddhif, Balkis
Poinot, Pauline
Clarhaut, Jonathan
Papot, Sébastien - Abstract:
- Abstract : Synthesis, in vitro and in vivo biological evaluations of a β-glucuronidase-responsive albumin-binding prodrug bearing a chemical amplifier. Abstract : We report on the synthesis, in vitro and in vivo biological evaluations of a dimeric β-glucuronidase-responsive albumin-binding prodrug designed for the double release of MMAE upon a single enzymatic activation step. This prodrug produced a significant antitumour activity in mice bearing subcutaneous LS174T colorectal adenocarcinoma xenografts without inducing side effects.
- Is Part Of:
- MedChemComm. Volume 9:Issue 12(2018)
- Journal:
- MedChemComm
- Issue:
- Volume 9:Issue 12(2018)
- Issue Display:
- Volume 9, Issue 12 (2018)
- Year:
- 2018
- Volume:
- 9
- Issue:
- 12
- Issue Sort Value:
- 2018-0009-0012-0000
- Page Start:
- 2068
- Page End:
- 2071
- Publication Date:
- 2018-11-15
- Subjects:
- Pharmaceutical chemistry -- Periodicals
615.19 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/md ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c8md00466h ↗
- Languages:
- English
- ISSNs:
- 2040-2503
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5424.685000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 9148.xml