Statistical methods for detecting admixture. (December 2018)

• Record Type: Journal Article
• Authors: Wangkumhang, Pongsakorn; Hellenthal, Garrett
• Is Part Of: Current opinion in genetics & development. Volume 53(2018)
• Page Start: 121
• Page End: 127
• Publication Date: 2018-12
• Subjects: Genetics -- Periodicals; Developmental biology -- Periodicals; Developmental genetics -- Periodicals; 576.5
• DOI: 10.1016/j.gde.2018.08.002
• Languages: English
• ISSNs: 0959-437X

Abstract

Abstract : The increasing availability of large-scale autosomal genetic variation data sampled from world-wide geographic areas, coupled with advances in the statistical methodology to analyse these data, is showcasing the power of DNA as a major tool to gain insights into the demographic history of humans and other organisms. Here we review statistical techniques that shed light on a specific aspect of demography: the detection and description of admixture events where two or more genetically distinct groups intermixed at one or more times in the past. In particular we give an overview of some of the widely used methods to identify and describe admixture events using autosomal DNA from unrelated individuals, with a particular focus on analysing biallelic Single-Nucleotide-Polymorphsim (SNP) markers.