Addition of high load of lysophosphatidic acid to standard and high‐fat chows causes no significant changes of its circulating and peripheral tissue levels but affects body weight and visceral fat mass of mice. (16th October 2018)

• Record Type: Journal Article
• Authors: Inoue, Manami; Okamoto, Yoko; Atsumi, Yuta; Shiojiri, Masatoshi; Hidaka, Mayumi; Tanaka, Tamotsu; Tsutsumi, Toshihiko; Shirasaka, Naoki; Tokumura, Akira
• Is Part Of: BioFactors. Volume 44:Number 6(2018)
• Page Start: 548
• Page End: 557
• Publication Date: 2018-10-16
• Subjects: body weight gain -- high‐fat chow -- lysophospholipid -- soybean lecithin -- visceral fat mass; Vitamins -- Physiological effect -- Periodicals; Trace elements -- Physiological effect -- Periodicals; Growth factors -- Physiological effect -- Periodicals; Plant growth promoting substances -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Nutritional Physiological Phenomena -- Periodicals; Trace Elements -- metabolism -- Periodicals; Vitamins -- metabolism -- Periodicals; Molecular Biology -- Periodicals; 612.399
• DOI: 10.1002/biof.1451
• Languages: English
• ISSNs: 0951-6433

Abstract

Abstract: Oral administration of lysophosphatidic acid (LPA), a critical intercellular lipid mediator, exerts wound healing and antiulcer effects on gastrointestinal system. To evaluate effects of food‐derived LPA on body homeostasis, we measured LPA levels by liquid chromatography–tandem mass spectrometry in chows, feces, plasma, liver, and visceral fat of mice fed a normal or high‐fat chow supplemented with or without LPA‐rich soybean phospholipids for 30 days. Reductions in daily body weight gains and visceral fat mass were mainly related to lower chow intake by mice fed the LPA‐rich high‐fat chow, whereas reduced body weight gains and fat mass were mainly related to decreased intestinal triacylglycerol absorption in mice fed LPA‐rich chow. Our results showed no significant increase in plasma, liver, or adipose LPA levels, even if a quite high LPA concentration (2.0%) in chows was ingested daily, suggesting limited effects of food‐derived LPA on the lumen side of the digestive tract. © 2018 BioFactors, 44(6):548–557, 2018