Pharmacokinetics and tissue residues of vancomycin after oral administration in crucian carp. (14th November 2018)

• Record Type: Journal Article
• Authors: Tang, Yunyu; Lou, Xiaoyi; Yang, Guangxin; Xi, Yinfeng; Zhang, Xuan; Ye, Hongli; Fang, Changling; Huang, Dongmei
• Is Part Of: Aquaculture research. Volume 50:Number 1(2019)
• Page Start: 268
• Page End: 276
• Publication Date: 2018-11-14
• Subjects: crucian carp -- pharmacokinetic -- residue -- vancomycin; Aquaculture -- Periodicals; Fishery management -- Periodicals; 639.8
• DOI: 10.1111/are.13892
• Languages: English
• ISSNs: 1355-557X

Abstract

Abstract: The pharmacokinetics and tissue residues of vancomycin in crucian carp ( Carassius auratus ) were studied after oral administration of a single dosage of 1 mg/kg body weight at water temperature of 18°C. The drug concentration‐time data were fitted using a two‐compartment open model with first‐order absorption. The vancomycin concentrations in plasma and tissues including muscle, liver and kidney were analyzed by means of liquid chromatography‐tandem mass spectrometry. As a result, the plasma absorption rate constant of vancomycin was 3.75/hr and the time point of maximum concentration in plasma was 3.0 hr respectively. The maximum concentration of vancomycin in plasma was 216.58 μg/L. The distribution half‐life and the elimination half‐life in plasma were 6.69 hr and 190 hr, as well as the absorption half‐life of plasma was 0.19/hr. The area under the plasma concentration‐time curve of plasma was 15.12 mg hr/L. The apparent volume of distribution of plasma was estimated to be 4.45 L/kg and the total body clearance was computed as 0.061 L hr −1 kg −1 . In addition, the maximum tissue concentrations of vancomycin were in the order of liver > kidney > muscle. To guarantee the safety of tissue samples for consumption, it was suggested that the withdrawal time should not be less than 30 days at 18°C. All these results may provide guidance for future vancomycin treatment in aquaculture.