Multifunctional Nanotherapeutics for Photothermal Combination Therapy of Cancer. Issue 8 (26th August 2018)

• Record Type: Journal Article
• Authors: Tian, Ye; Guo, Ranran; Yang, Wuli
• Is Part Of: Advanced therapeutics. Volume 1:Issue 8(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-08-26
• Subjects: anticancer -- combination therapy -- nanoparticles -- photothermal therapy; Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.201800049
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract: Recently, photothermal therapy (PTT) has demonstrated excellent results in the treatment of preclinical cancer models and thus attracted intensive interests from the research fields of material science, biochemistry, oncology, and pharmacy. Also, its combination with other cancer therapies shows great promise for clinical application: PTT is able to make up for the drawbacks of others and improve the prognosis through various synergistic effects. In these combination therapies, design of nanoscale multifunctional therapeutics is key to achieve enhanced or even synergistic therapeutic effect. Herein, the recent progress is summarized in the development of strategies involving combination of PTT with other cancer therapies, conventional or emerging, with increased efficacy. The highlight lies in integrating various functional units to form multifunctional nanomaterials that play the role of photothermal agents as well as other therapeutics in a combination therapy and the design of an effective targeted delivery system for them. Smart combination of therapies will undoubtedly improve the therapeutic efficacy and make a contribution to the advancement in fighting cancer. Abstract : Photothermal therapy (PTT) and its combination with other oncotherapies demonstrates great clinical potential in the treatment of cancer. This progress report summarizes recently reported strategies aiming at combination of PTT and others and highlights smart designs of nanoscale multifunctional therapeutics that are able to achieve a synergistic effect and improved therapeutic efficacy in the treatment.