A simple and mild Suzuki reaction protocol using triethylamine as base and solvent. Issue 24 (17th December 2018)

• Record Type: Journal Article
• Authors: Li, Xinmin; Zhang, Hang; Hu, Qinghong; Jiang, Bo; Zeli, Yuan
• Is Part Of: Synthetic communications. Volume 48:Issue 24(2018)
• Page Start: 3123
• Page End: 3132
• Publication Date: 2018-12-17
• Subjects: Ligand-free -- one-pot -- Suzuki reaction -- terphenyls -- triethylamine; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2018.1519075
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: A simple and mild protocol for the palladium-catalyzed Suzuki reaction of aryl bromides and arylboronic acids is developed. The cross-coupling reactions can be performed at room temperature using 5.0 equiv. of Et3 N as solvent and base without any ligands, and affording biaryl products in good yields. In addition, the chemoselecitive Suzuki reaction of bromo- N -methyliminodiacetic acid (MIDA) boronates with arylboronic acids can be achieved in this system, and various unsymmetrical terphenyls have been prepared in moderate yields by one-pot double Suzuki reactions. GRAPHICAL ABSTRACT: