Tracing the protective activity of Lactobacillus plantarum using technetium-99m-labeled zearalenone for organ toxicity. (2nd December 2018)

• Record Type: Journal Article
• Authors: Sanad, M. H.; Fouzy, A. S. M.; Sobhy, Hassan M.; Hathout, Amal S.; Hussain, Omaima A.
• Is Part Of: International journal of radiation biology. Volume 94:Number 12(2018)
• Page Start: 1151
• Page End: 1158
• Publication Date: 2018-12-02
• Subjects: Technetium-[99m] -- zearalenone -- distribution -- organ toxicity -- mice -- L. plantarum; Radiation -- Physiological effect -- Periodicals; Radiobiology -- Periodicals; 571.45
• DOI: 10.1080/09553002.2019.1524990
• Languages: English
• ISSNs: 0955-3002

Abstract

Abstract: Purpose: Zearalenone is a potent estrogenic metabolite produced by some Fusarium and Gibberella species. Therefore, the aim of this study was to determine the accumulation of Technetium-[ 99m ]-labeled zearalenone in mice organs as well as to study the protective effect of Lactobacillus plantarum . Materials and methods: Two different groups of mice were used; the first group of mice received Technetium-[ 99m ]-zearalenone only, and the second group received both Technetium-[ 99m ] zearalenone and L. plantarum (as a protective agent). Technetium-[ 99m ]-labeled zearalenone was administered to mice by tail vein injection and L. plantarum was administered orally. Accumulation of labeled zearalenone in mice was monitored for 120 min. Results: Labeled zearalenone was distributed primarily in the intestine (44.5%) and liver (20.12%) after 120 min in the first group of mice. In the second group of mice which received both Technetium-[ 99m ] zearalenone and L. plantarum, labeled zearalenone was accumulated primarily in the intestine (46.8%) and liver (18.9%). These results indicated the decrease in labeled zearalenone in the liver due to the effect of lactic acid bacteria. Conclusion: Technetium-[ 99m ]-labeled zearalenone can be used as a new tracer for organ imaging and that L. plantarum can decrease the bioavailability of zearalenone in mice organs.