Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice. (2nd October 2018)

• Record Type: Journal Article
• Authors: Zha, Meng; Tao, Qingping; Li, Jun; Tian, Xiaofei; Feng, Shuang; Liao, Zhongcai; Fang, Zhicai; Zhang, Xin
• Is Part Of: Electromagnetic biology and medicine. Volume 37:Number 4(2018)
• Page Start: 192
• Page End: 201
• Publication Date: 2018-10-02
• Subjects: Rotating magnetic field (RMF) -- Low frequency Rotating magnetic field (LF-RMF) -- moderate intensity low frequency rotating magnetic field -- breast cancer -- gastrointestinal stromal tumor; Electrophysiology -- Periodicals; Electromagnetic Fields -- Periodicals; Electrophysiology -- Periodicals; Radiation, Nonionizing -- Periodicals; 574
• DOI: 10.1080/15368378.2018.1506989
• Languages: English
• ISSNs: 1536-8378

Abstract

ABSTRACT: Moderate intensity low frequency rotating magnetic field (LF-RMF) has been shown to inhibit melanoma, liver and lung cancer growth in mice. However, its effects on other types of cancers have not been investigated in vivo . Here, we show that 0–0.15T moderate intensity 4.2 Hz LF-RMF can inhibit tumor growth in mice bearing MDA-MB231 and MCF7 human breast cancer cells by over 30%. In contrast, the human gastrointestinal stromal tumor GIST-T1 growth was not inhibited by LF-RMF. In all RMF treatments, there were no apparent adverse effects on mice organs, body weight or water/food consumptions. However, the alanine aminotransferase (ALT) level was decreased in LF-RMF-treated mice bearing MCF7 and GIST-T1 cells, which indicated alleviated liver damage. Therefore, our study shows that moderate intensity LF-RMF might be a safe physical method that has clinical potentials to be used to inhibit breast cancer growth in the future.