Facile synthesis of 2, 3-disubstituted benzofurans via DBU-promoted intramolecular annulation of ortho oxyether aroylformates. Issue 24 (17th December 2018) - Liu, Rongfang
Abstract: A facile synthesis of 2, 3-disubstituted benzofurans from ortho oxyether aroylformates has been developed. Under the mediation of DBU, the intramolecular annulation of ortho oxyether aroylformates proceeds smoothly to provide the corresponding 2, 3-disubstituted benzofurans in moderate to good yields under mild conditions. Furthermore, a one-pot two-step synthesis of 2, 3-disubstituted benzofurans has also been demonstrated from readily available ortho hydroxy aroylformates. GRAPHICAL ABSTRACT: