Effects of prophylactic oral ibuprofen on the closure rate of patent ductus arteriosus in premature infants. Issue 37 (September 2018)

• Record Type: Journal Article
• Authors: Ding, Yanjie; Wang, Xuan; Wu, Yanqiu; Li, Hui; Xu, Jiaju; Wang, Xiaoliang
• Other Names: Moawad. Eman Mohamed I. section editor.
• Is Part Of: Medicine. Volume 97:Issue 37(2018)
• Publication Date: 2018-09
• Subjects: ibuprofen -- patent ductus arteriosus -- premature infants; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000012206
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: The aim of this study was to investigate the effects of prophylactic oral ibuprofen on the closure rate of patent ductus arteriosus (PDA). This was a retrospective study and data on infants born before 36 weeks were collected. The prophylactic group was treated with ibuprofen (10, 5, and 5 mg/kg) from days 1 to 3 after birth, respectively. The conventional group was treated with the same dose of ibuprofen from days 4 to 6 once they were echocardiographically confirmed with PDA on day 3 after birth. The placebo group was treated with 5% glucose. The closure rate of PDA in the prophylactic group significantly increased on day 7 compared with the placebo group ( P = .02), but showed no difference compared with the conventional group ( P = .12). Serum NT-proBNP in the prophylactic and conventional groups decreased compared with the placebo group ( P = .03 vs P = .07). Prophylactic oral ibuprofen can increase the closure rate of PDA in premature infants; however, it showed no significant advantages compared with conventional treatment. Serum NT-proBNP can be used to observe PDA treatment responses in premature infants.