Blood pressure-lowering interventions to prevent dementia: a systematic review and meta-analysis. Issue 9 (September 2018)

• Record Type: Journal Article
• Authors: van Middelaar, Tessa; van Vught, Lonneke A.; van Gool, Willem A.; Simons, Esther M.F.; van den Born, Bert-Jan H.; Moll van Charante, Eric P.; Richard, Edo
• Is Part Of: Journal of hypertension. Volume 36:Issue 9(2018:Sep.)
• Publication Date: 2018-09
• Subjects: antihypertensive agents -- dementia -- healthy lifestyle -- hypertension -- preventive medicine; Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/HJH.0000000000001829
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : N/A: Our objective was to study the preventive effect of lowering blood pressure (BP) by medication and/or lifestyle changes on incident all-cause dementia, Alzheimer's disease and vascular dementia. In this systematic review, we included randomized controlled trials with a BP-lowering intervention. Of the nine included trials, seven assessed the effect of antihypertensive medication and two of a lifestyle or combined intervention. In the intervention arm, 1041 out of 29 029 (3.6%) participants were diagnosed with dementia compared with 1090 out of 28 653 (3.8%) controls during a median follow-up of 3.9 years [range 2–10], resulting in a pooled risk ratio of 0.93 (95% confidence interval 0.84–1.02; I 2 16%). Three trials specified dementia subtypes, with no significant effect on Alzheimer's disease or vascular dementia. To conclude, lowering BP by medication and/or lifestyle changes did not lead to a significantly reduced risk of dementia. This appeared independent of dementia subtype. Abstract : Supplemental Digital Content is available in the text