Effects of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-ischemic Encephalopathy. Issue 3 (September 2018)

• Record Type: Journal Article
• Authors: Laptook, A.R.; Shankaran, S.; Tyson, J.E.; Munoz, B.; Bell, E.F.; Goldberg, R.N.; Parikh, N.A.; Ambalavanan, N.; Pedroza, C.; Pappas, A.; Das, A.; Chaudhary, A.S.; Ehrenkranz, R.A.; Hensman, A.M.; Van Meurs, K.P.; Chalak, L.F.; Hamrick, S.E.G.; Sokol, G.M.; Walsh, M.C.; Poindexter, B.B.; Faix, R.G.; Watterberg, K.L.; Frantz, I.D.; Guillet, R.; Devaskar, U.; Truog, W.E.; Chock, V.Y.; Wyckoff, M.H.; McGowan, E.C.; Carlton, D.P.; Harmon, H.M.; Brumbaugh, J.E.; Cotten, C.M.; Sánchez, P.J.; Hibbs, A.M.; Higgins, R.D.;
• Is Part Of: Obstetric anesthesia digest. Volume 38:Issue 3(2018)
• Publication Date: 2018-09
• Subjects: Neonatal Morbidity and Mortality -- Systems-based Practice -- Obstetric Complications; Anesthesia in obstetrics -- Periodicals; Anesthesia in obstetrics -- Abstracts -- Periodicals; 617.968205
• DOI: 10.1097/01.aoa.0000542372.34481.78
• Languages: English
• ISSNs: 0275-665X

Abstract

Abstract : ( JAMA 2017;318(16):1550–1560) Previous trials have shown therapeutic hypothermia reduces death or disability when infants with hypoxic-ischemic encephalopathy are treated within 6 hours after birth. Getting infants treated in this window can be difficult when transportation is necessary or when encephalopathy is not recognized within 6 hours. This study aimed to determine whether hypothermia treatment can reduce the risk of death or disability due to hypoxic-ischemic encephalopathy at 18 months when treatment is initiated between 6 and 24 hours after birth.