Preexisting Diabetes Elevates Risk of Local and Systemic Complications in Acute Pancreatitis: Systematic Review and Meta-analysis. Issue 8 (September 2018)

• Record Type: Journal Article
• Authors: Mikó, Alexandra; Farkas, Nelli; Garami, András; Szabó, Imre; Vincze, Áron; Veres, Gábor; Bajor, Judit; Alizadeh, Hussain; Rakonczay, Zoltán; Vigh, Éva; Márta, Katalin; Kiss, Zoltán; Hegyi, Péter; Czakó, László
• Is Part Of: Pancreas. Volume 47:Issue 8(2018)
• Publication Date: 2018-09
• Subjects: acute pancreatitis -- complications -- diabetes mellitus -- mortality -- length of hospitalization; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000001122
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Abstract: The prevalence of diabetes mellitus (DM) and acute pancreatitis (AP) increases continuously, therefore, to understand the effects of preexisting diabetes on AP is crucially needed. Here, we performed a systematic review and meta-analysis in which AP patients including DM and non-DM groups were sorted. Several outcome parameters were analyzed, and the odds ratio (OR) and standardized mean difference with 95% confidence intervals (CIs) were calculated. We found 1417 articles, of which 9 articles involving 354, 880 patients were analyzed. More complications were seen in diabetic patients than in non-DM patients (OR, 1.553 [95% CI, 1.266–1.904]; P < 0.001). Intensive care unit admission (OR, 1.799 [95% CI, 1.442–2.243]; P < 0.001) and renal failure (OR, 1.585 [95% CI, 1.278–1.966]; P < 0.001) were more frequent in DM patients. There was a tendency of higher mortality and local complications (OR, 1.276 [95% CI, 0.991–1.643]; P = 0.059; and OR, 1.267 [95% CI, 0.964–1.659]; P = 0.090, respectively) in preexisting DM. Length of hospitalization was longer in DM patients (standardized mean difference, 0.217 [95% CI, 0.075–0.360]; P = 0.003). Preexisting DM negatively influences the outcome of AP and increases the risk of renal failure, local complications, and mortality. Abstract : Supplemental digital content is available in the text.