Survival of women with cancers of breast and genital organs in Europe 1999–2007: Results of the EUROCARE-5 study. Issue 15 (October 2015)

• Record Type: Journal Article
• Authors: Hackl, M.; Zielonke, N.; Oberaigner, W.; Van Eycken, E.; Henau, K.; Valerianova, Z.; Dimitrova, N.; Sekerija, M.; Zvolský, M.; Dušek, L.; Storm, H.; Engholm, G.; Mägi, M.; Aareleid, T.; Malila, N.; Seppä, K.; Velten, M.; Troussard, X.; Bouvier, V.; Launoy, G.; Guizard, A.V.; Faivre, J.; Bouvier, A.M.; Arveux, P.; Maynadié, M.; Woronoff, A.S.; Robaszkiewicz, M.; Baldi, I.; Monnereau, A.; Tretarre, B.; Bossard, N.; Belot, A.; Colonna, M.; Molinié, F.; Bara, S.; Schvartz, C.; Lapôtre-Ledoux, B.; Grosclaude, P.; Meyer, M.; Stabenow, R.; Luttmann, S.; Eberle, A.; Brenner, H.; Nennecke, A.; Engel, J.; Schubert-Fritschle, G.; Kieschke, J.; Heidrich, J.; Holleczek, B.; Katalinic, A.; Jónasson, J.G.; Tryggvadóttir, L.; Comber, H.; Mazzoleni, G.; Bulatko, A.; Buzzoni, C.; Giacomin, A.; Sutera Sardo, A.; Mancuso, P.; Ferretti, S.; Crocetti, E.; Caldarella, A.; Gatta, G.; Sant, M.; Amash, H.; Amati, C.; Baili, P.; Berrino, F.; Bonfarnuzzo, S.; Botta, L.; Di Salvo, F.; Foschi, R.; Margutti, C.; Meneghini, E.; Minicozzi, P.; Trama, A.; Serraino, D.; Dal Maso, L.; De Angelis, R.; Caldora, M.; Capocaccia, R.; Carrani, E.; Francisci, S.; Mallone, S.; Pierannunzio, D.; Roazzi, P.; Rossi, S.; Santaquilani, M.; Tavilla, A.; Pannozzo, F.; Busco, S.; Bonelli, L.; Vercelli, M.; Gennaro, V.; Ricci, P.; Autelitano, M.; Randi, G.; Ponz De Leon, M.; Marchesi, C.; Cirilli, C.; Fusco, M.; Vitale, M.F.; Usala, M.; Traina, A.; Staiti, R.; Vitale, F.; Ravazzolo, B.; Michiara, M.; Tumino, R.; Giorgi Rossi, P.; Di Felice, E.; Falcini, F.; Iannelli, A.; Sechi, O.; Cesaraccio, R.; Piffer, S.; Madeddu, A.; Tisano, F.; Maspero, S.; Fanetti, A.C.; Zanetti, R.; Rosso, S.; Candela, P.; Scuderi, T.; Stracci, F.; Bianconi, F.; Tagliabue, G.; Contiero, P.; Dei Tos, A.P.; Guzzinati, S.; Pildava, S.; Smailyte, G.; Calleja, N.; Agius, D.; Johannesen, T.B.; Rachtan, J.; Gózdz, S.; Mezyk, R.; Blaszczyk, J.; Bebenek, M.; Bielska-Lasota, M.; Forjaz de Lacerda, G.; Bento, M.J.; Castro, C.; Miranda, A.; Mayer-da-Silva, A.; Nicula, F.; Coza, D.; Safaei Diba, C.; Primic-Zakelj, M.; Almar, E.; Ramírez, C.; Errezola, M.; Bidaurrazaga, J.; Torrella-Ramos, A.; Díaz García, J.M.; Jimenez-Chillaron, R.; Marcos-Gragera, R.; Izquierdo Font, A.; Sanchez, M.J.; Chang, D.Y.L.; Navarro, C.; Chirlaque, M.D.; Moreno-Iribas, C.; Ardanaz, E.; Galceran, J.; Carulla, M.; Lambe, M.; Khan, S.; Mousavi, M.; Bouchardy, C.; Usel, M.; Ess, S.M.; Frick, H.; Lorez, M.; Ess, S.M.; Herrmann, C.; Bordoni, A.; Spitale, A.; Konzelmann, I.; Visser, O.; Lemmens, V.; Coleman, M.; Allemani, C.; Rachet, B.; Verne, J.; Easey, N.; Lawrence, G.; Moran, T.; Rashbass, J.; Roche, M.; Wilkinson, J.; Gavin, A.; Donnelly, C.; Brewster, D.H.; Huws, D.W.; White, C.; Otter, R.; Sant, Milena; Chirlaque Lopez, Maria Dolores; Agresti, Roberto; Sánchez Pérez, Maria José; Holleczek, Bernd; Bielska-Lasota, Magdalena; Dimitrova, Nadya; Innos, Kaire; Katalinic, Alexander; Langseth, Hilde; Larrañaga, Nerea; Rossi, Silvia; Siesling, Sabine; Minicozzi, Pamela;
• Is Part Of: European journal of cancer. Volume 51:Issue 15(2015:Oct.)
• Page Start: 2191
• Page End: 2205
• Publication Date: 2015-10
• Subjects: Breast cancer -- Corpus uteri cancer -- Cervical cancer -- Ovarian cancer -- Vaginal cancer -- Vulval cancer -- Europe -- Population-based -- Survival; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2015.07.022
• Languages: English
• ISSNs: 0959-8049

Abstract

Abstract: Background: Survival differences across Europe for patients with cancers of breast, uterus, cervix, ovary, vagina and vulva have been documented by previous EUROCARE studies. In the present EUROCARE-5 study we update survival estimates and investigate changes in country-specific and over time survival, discussing their relationship with incidence and mortality dynamics for cancers for which organised screening programs are ongoing. Methods: We analysed cases archived in over 80 population-based cancer registries in 29 countries grouped into five European regions. We used the cohort approach to estimate 5-year relative survival (RS) for adult (⩾15 years) women diagnosed 2000–2007, by age, country and region; and the period approach to estimate time trends (1999–2007) in RS for breast and cervical cancers. Results: In 2000–2007, 5-year RS was 57% overall, 82% for women diagnosed with breast, 76% with corpus uteri, 62% with cervical, 38% with ovarian, 40% with vaginal and 62% with vulvar cancer. Survival was low for patients resident in Eastern Europe (34% ovary–74% breast) and Ireland and the United Kingdom [Ireland/UK] (31–79%) and high for those resident in Northern Europe (41–85%) except Denmark. Survival decreased with advancing age: markedly for women with ovarian (71% 15–44 years; 20% ⩾75 years) and breast (86%; 72%) cancers. Survival for patients with breast and cervical cancers increased from 1999–2001 to 2005–2007, remarkably for those resident in countries with initially low survival. Conclusions: Despite increases over time, survival for women's cancers remained poor in Eastern Europe, likely due to advanced stage at diagnosis and/or suboptimum access to adequate care. Low survival for women living in Ireland/UK and Denmark could indicate late detection, possibly related also to referral delay. Poor survival for ovarian cancer across the continent and over time suggests the need for a major research effort to improve prognosis for this common cancer.