Estimation of Bone Loss Biomarkers as a Diagnostic Tool for Peri‐Implantitis. Issue 11 (1st November 2014)

• Record Type: Journal Article
• Authors: Rakic, Mia; Struillou, Xavier; Petkovic‐Curcin, Aleksandra; Matic, Smiljana; Canullo, Luigi; Sanz, Mariano; Vojvodic, Danilo
• Is Part Of: Journal of periodontology. Volume 85:Issue 11(2014)
• Page Start: 1566
• Page End: 1574
• Publication Date: 2014-11-01
• Subjects: Biological markers -- cathepsin K -- osteoprotegerin -- peri‐implantitis -- RANK ligand; Periodontics -- Periodicals; 617.632
• DOI: 10.1902/jop.2014.140069
• Languages: English
• ISSNs: 0022-3492

Abstract

Abstract : Background: The aims of this study are to estimate the profile of bone loss biomarkers in peri‐implant tissues and to identify potential prognostic biomarkers of peri‐implantitis. Methods: Peri‐implant crevicular fluid samples collected from 164 participants (52 patients with peri‐implantitis, 54 with mucositis, and 58 with healthy peri‐implant tissues) were analyzed using enzyme‐linked immunosorbent assays to evaluate concentrations of the receptor activator of nuclear factor‐κB (RANK), soluble RANK ligand (sRANKL), osteoprotegerin (OPG), cathepsin‐K, and sclerostin. Results: Concentrations of RANK, sRANKL, OPG, and sclerostin were significantly increased in patients with peri‐implantitis compared with patients with healthy peri‐implant tissues. Comparisons between peri‐implantitis and mucositis demonstrated significantly higher values of sclerostin in peri‐implantitis samples. Comparisons between mucositis and healthy peri‐implant tissues showed significantly increased levels of RANK and cathepsin‐K in mucositis. Conclusion: These results are suggestive of a role of sRANKL, OPG, and sclerostin as prognostic biomarkers in peri‐implantitis.