Long‐Term Stability After Regenerative Treatment of Infrabony Defects: A Retrospective Case Series. Issue 6 (1st June 2017)

• Record Type: Journal Article
• Authors: Nickles, Katrin; Dannewitz, Bettina; Gallenbach, Kerstin; Ramich, Tatjana; Scharf, Susanne; Röllke, Lasse; Schacher, Beate; Eickholz, Peter
• Is Part Of: Journal of periodontology. Volume 88:Issue 6(2017)
• Page Start: 536
• Page End: 542
• Publication Date: 2017-06-01
• Subjects: Enamel matrix proteins -- guided tissue regeneration, periodontal -- periodontal attachment loss -- periodontitis -- secondary prevention -- surgical procedures, operative; Periodontics -- Periodicals; 617.632
• DOI: 10.1902/jop.2017.160704
• Languages: English
• ISSNs: 0022-3492

Abstract

Abstract : Background: This study aims to evaluate long‐term stability of attachment achieved in infrabony defects (IBDs) by regenerative treatment. Methods: All patients who had received regenerative treatment for at least one IBD between 2004 and 2010 were screened for this retrospective case series. If complete examinations (plaque/gingival index, probing depth [PD], vertical clinical attachment level [CAL‐V]) were available for patients at baseline and 12 months after surgery, they were invited for reexamination 60 ± 12 months after surgery. Reexamination involved testing for interleukin (IL)‐1 polymorphism and counting number of supportive periodontal treatment (SPT) visits. Forty‐one patients (24 males and 17 females; age, median: 62.0 years, lower/upper quartile: 49.8/68.3 years; six smokers, and 9 IL‐1 positive) were included for analysis, each contributing one IBD. Results: Regenerative therapy resulted in significant attachment gain after 1 (median: −3 mm, lower/upper quartile: −1.5/−4 mm; P <0.001) and 5 (median: −3 mm, lower/upper quartile: −1.9/4.5 mm; P <0.001) years. The study failed to detect median change of CAL‐V from 1 to 5 years after surgery (median: 0 mm; lower/upper quartile: −1/1.5 mm; P = 0.84). Multiple regression analysis identified that number of SPT visits is correlated with CAL‐V gain from 1 to 5 years after surgery. IL‐1 polymorphism and percentage of sites with PD >6 mm at 5‐year reexamination are correlated with CAL‐V loss from 1 to 5 years after surgery. Conclusions: CAL‐V achieved by regenerative therapy in IBDs may have retained stability over 5 years. Frequent SPT is associated with stability. IL‐1 polymorphism and generalized reinfection are associated with less stability.