Cover Feature: Conformational Bias by a Removable Silyl Group: Construction of Bicyclo[n.3.1]alkenes by Ring Closing Metathesis (Chem. Eur. J. 10/2018). Issue 10 (19th December 2017)

• Record Type: Journal Article
• Authors: Lin, Minggui; Cai, Pei‐Jun; Zeng, Zhixiong; Lin, Na; Shen, Yang; Tang, Bin; Li, Fan; Chen, Chen; Yu, Zhi‐Xiang; Zhang, Yandong
• Is Part Of: Chemistry. Volume 24:Issue 10(2018)
• Page Start: 2293
• Page End: 2293
• Publication Date: 2017-12-19
• Subjects: bridged ring systems -- conformational control -- density functional calculations -- natural products -- ring-closing metathesis; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201705829
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : A conformationally controlled ring‐closing metathesis through a removable silyl group has been developed for the synthesis of challenging bridged carbocycles. These include bicyclo[ n .3.1]alkenes, in particular, a set of highly strained bicyclo[5.3.1]alkenes. The utility of the methodology was demonstrated by a concise synthesis of the A‐B‐C ring skeleton of Taxol. More information can be found in the Communication by Z.‐X. Yu, Y. Zhang et al. onpage 2334 .