Cover Feature: Synthesis of a Novel Type of 2, 3′‐BIMs via Platinum‐Catalysed Reaction of Indolylallenes with Indoles (Chem. Eur. J. 23/2018). Issue 23 (24th March 2018)

• Record Type: Journal Article
• Authors: Cooper, Lisa; Alonso, José Miguel; Eagling, Louise; Newson, Helen; Herath, Sachini; Thomson, Christopher; Lister, Andrew; Howsham, Catherine; Cox, Brian; Muñoz, María Paz
• Is Part Of: Chemistry. Volume 24:Issue 23(2018)
• Page Start: 5989
• Page End: 5989
• Publication Date: 2018-03-24
• Subjects: allenes -- heterocycles -- indoles -- reaction mechanisms -- platinum; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201801038
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Organometallic synthesis is a powerful tool to make novel molecules with frameworks not encountered in natural products. In this context the platinum‐catalysed reaction of indolylallenes with indole nucleophiles was discovered which gives substituted tetrahydropyrido[1, 2a]indoles, an original type of 2, 3′‐BIM with a framework not observed thus far in nature and of interest to the pharmaceutical industry. The reaction is unique to platinum catalysis and the study of the mechanism uncovered a complex reaction pathway that may help in the understanding of the divergent reactivity of platinum compared to other metals. More information can be found in the Full Paper by M. P. Muñoz, et al. onpage 6105 .