The Adjunctive Effect of Platelet‐Rich Fibrin to Connective Tissue Graft in the Treatment of Buccal Recession Defects: Results of a Randomized, Parallel‐Group Controlled Trial. Issue 11 (1st November 2015)

• Record Type: Journal Article
• Authors: Keceli, Huseyin Gencay; Kamak, Gulen; Erdemir, Ebru Olgun; Evginer, Mustafa Serdar; Dolgun, Anil
• Is Part Of: Journal of periodontology. Volume 86:Issue 11(2015)
• Page Start: 1221
• Page End: 1230
• Publication Date: 2015-11-01
• Subjects: Connective tissue -- gingiva -- gingival recession -- platelet‐rich plasma -- tissue transplantation -- surgical flaps; Periodontics -- Periodicals; 617.632
• DOI: 10.1902/jop.2015.150015
• Languages: English
• ISSNs: 0022-3492

Abstract

Abstract : Background: Platelet‐rich fibrin (PRF) is an autologous preparation that has encouraging effects in healing and regeneration. The aim of this trial is to evaluate the effectiveness of coronally advanced flap (CAF) + connective tissue graft (CTG) + PRF in Miller Class I and II recession treatment compared to CAF + CTG. Methods: Forty patients were treated surgically with either CAF + CTG + PRF (test group) or CAF + CTG (control group). Clinical parameters of plaque index, gingival index, vertical recession (VR), probing depth, clinical attachment level (CAL), keratinized tissue width (KTW), horizontal recession (HR), mucogingival junction localization, and tissue thickness (TT) were recorded at baseline and 3 and 6 months after surgery. Root coverage (RC), complete RC (CRC), attachment gain (AG), and keratinized tissue change (KTC) were also calculated. Results: All individuals completed the entire study period. At baseline, mean VR, HR, CAL, KTW, and TT values were similar ( P >0.05). In both groups, all parameters showed significant improvement after treatment ( P <0.001), and except TT ( P <0.05), no intergroup difference was observed at 6 months after surgery. The amount of RC and AG, but not KTC and CRC, was higher in the PRF‐applied group ( P <0.05). Conclusions: According to the results, the addition of PRF did not further develop the outcomes of CAF + CTG treatment except increasing the TT. However, this single trial is not sufficient to advocate the true clinical effect of PRF on recession treatment with CAF + CTG, and additional trials are needed.