Comparative Analysis of Calcium‐Binding Myeloid‐Related Protein‐8/14 in Saliva and Serum of Patients With Periodontitis and Healthy Individuals. Issue 2 (1st February 2016)

• Record Type: Journal Article
• Authors: Haririan, Hady; Andrukhov, Oleh; Pablik, Eleonore; Neuhofer, Michaela; Moritz, Andreas; Rausch‐Fan, Xiaohui
• Is Part Of: Journal of periodontology. Volume 87:Issue 2(2016)
• Page Start: 184
• Page End: 192
• Publication Date: 2016-02-01
• Subjects: Biological markers -- calcium -- calcium‐binding proteins -- leukocyte L1 antigen complex -- periodontitis -- saliva; Periodontics -- Periodicals; 617.632
• DOI: 10.1902/jop.2015.150254
• Languages: English
• ISSNs: 0022-3492

Abstract

Abstract : Background: This study aims to investigate calcium‐binding myeloid‐related protein (MRP)‐8/14 in the saliva and serum of individuals with periodontitis and periodontally healthy individuals for the assessment of its role in the pathogenesis and clinical diagnosis of periodontitis. Methods: This cross‐sectional study includes 56 patients with periodontitis and 44 periodontally healthy individuals. Saliva and serum were collected for the detection of MRP‐8/14 and calcium levels. Periodontopathic bacteria were determined by polymerase chain reaction in saliva. Correlations between salivary and serum MRP‐8/14 levels and clinical parameters, bacteria, and calcium were analyzed with Pearson correlation in a multiple regression model. MRP‐8/14 levels were documented with receiver operating characteristic (ROC) curves. Results: Compared with healthy individuals, MRP‐8/14 levels were significantly higher in both the saliva and serum of patients with periodontitis, but calcium was increased only in saliva. A high diagnostic potential of salivary MRP‐8/14 was detected for periodontitis (ROC = 0.86). Salivary MRP‐8/14 levels correlated significantly with the presence of the periodontopathogen Treponema denticola, as well as with the clinical parameters of periodontitis. Conclusion: MRP‐8/14 in saliva might be a potential diagnostic parameter for periodontal disease.