Cobalt‐Copper Catalyzed C(sp2) – N Cross Coupling of Amides or Nitrogenated Heterocycles with Styrenyl or Aryl Halides. Issue 16 (24th April 2018)

• Record Type: Journal Article
• Authors: Ghosh, Tubai; Maity, Pintu; Ranu, Brindaban C.
• Is Part Of: ChemistrySelect. Volume 3:Issue 16(2018)
• Page Start: 4406
• Page End: 4412
• Publication Date: 2018-04-24
• Subjects: Amide -- Cobalt/copper catalyst -- Cross coupling -- Enamide -- Styrenyl halide; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201800575
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: An efficient C(sp2) – N cross coupling of cyclic and acyclic amides with styrenyl/aryl/heteroaryl halides catalyzed by cobalt acetylacetonate in combination with copper(I) iodide, has been achieved. A library of diversely substituted cyclic and acyclic enamides have been obtained in high yields by this procedure. The reaction is stereoselective producing ( E )–enamides from trans ‐styrenyl halides and ( Z )‐ products from cis ‐halides. This procedure has been successfully employed for the coupling of other N‐heterocycles such as pyrazole, imidazole and triazole with aryl/styrenyl/heteroaryl halides to produce the corresponding N‐coupled products. A probable mechanism has been suggested. Abstract : An efficient Co/Cu catalyzed C(sp2) – N cross coupling of amides and styrenyl/aryl Halides leading to the synthesis of enamides has been achieved.