Relationship Between Serologic Markers of Periodontal Bacteria and Metabolic Syndrome and Its Components. Issue 3 (1st March 2015)

• Record Type: Journal Article
• Authors: Shrestha, Deepika; Choi, Youn‐Hee; Zhang, Jiajia; Hazlett, Linda J.; Merchant, Anwar T.
• Is Part Of: Journal of periodontology. Volume 86:Issue 3(2015)
• Page Start: 418
• Page End: 430
• Publication Date: 2015-03-01
• Subjects: Diabetes mellitus -- metabolic syndrome X -- microbiology; Periodontics -- Periodicals; 617.632
• DOI: 10.1902/jop.2014.140408
• Languages: English
• ISSNs: 0022-3492

Abstract

Abstract : Background: Periodontitis is a result of a complex biologic alteration of the periodontal microenvironment and a distributional shift of key periodontal pathogens. Metabolic syndrome (MetS), a complex cluster of cardiovascular risk factors, has been linked to periodontal diseases; however, the contribution of periodontal bacteria to systemic conditions remains unclear. Methods: The study population comprised 7, 848 United States adults who participated in an interview, underwent a clinical oral‐health examination, and had serum immunoglobulin G titers measured against 19 periodontal bacteria as part of the third National Health and Nutritional Examination Survey. The z‐score antibody titers were clustered into four mutually exclusive groups and named after Socransky's classification of periodontal bacteria (Orange‐Red, Red‐Green, Yellow‐Orange, and Orange‐Blue). Survey logistic regression was used to investigate the independent associations between the cluster scores, and MetS and each component, including hypertension, hypertriglyceridemia, low high‐density lipoprotein cholesterol, central obesity, and elevated fasting glucose. Results: The Orange‐Red cluster score (that included Porphyromonas gingivalis and Prevotella spp.) was positively associated (odds ratio [OR] = 1.067, 95% confidence interval [CI] = 1.02 to 1.12) and the Orange‐Blue cluster score (which included Actinomyces naeslundii and Eubacterium nodatum ) was inversely associated (OR = 0.93, 95% CI = 0.88 to 0.97) with elevated fasting glucose (≥110 mg/dL) after adjustment for clusters and potential confounders. Neither MetS nor its other remaining MetS components were associated with a particular cluster score. Conclusions: The associations between specific antibody clusters (Orange‐Red and Orange‐Blue) against periodontal bacteria and elevated plasma glucose were in qualitatively opposite directions after multivariable adjustment in a large, adult population. The periodontal bacterial profile was not found to be associated with metabolic control other than a very moderate association with elevated plasma glucose.