Meta-analysis of regional white matter volume in bipolar disorder with replication in an independent sample using coordinates, T-maps, and individual MRI data. (January 2018)

• Record Type: Journal Article
• Authors: Pezzoli, Stefania; Emsell, Louise; Yip, Sarah W.; Dima, Danai; Giannakopoulos, Panteleimon; Zarei, Mojtaba; Tognin, Stefania; Arnone, Danilo; James, Anthony; Haller, Sven; Frangou, Sophia; Goodwin, Guy M.; McDonald, Colm; Kempton, Matthew J.
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 84(2018)
• Page Start: 162
• Page End: 170
• Publication Date: 2018-01
• Subjects: Bipolar disorder -- Meta-analysis -- VBM -- MRI -- White matter; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2017.11.005
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: The meta-analysis revealed reductions of white matter volume in the posterior corpus callosum extending to the cingulate cortex. The result was replicated in a completely independent dataset. There was no association with clinical variables suggesting this may be a trait maker of the illness. Abstract: Converging evidence suggests that bipolar disorder (BD) is associated with white matter (WM) abnormalities. Meta-analyses of voxel based morphometry (VBM) data is commonly performed using published coordinates, however this method is limited since it ignores non-significant data. Obtaining statistical maps from studies (T-maps) as well as raw MRI datasets increases accuracy and allows for a comprehensive analysis of clinical variables. We obtained coordinate data (7-studies), T-Maps (12-studies, including unpublished data) and raw MRI datasets (5-studies) and analysed the 24 studies using Seed-based d Mapping (SDM). A VBM analysis was conducted to verify the results in an independent sample. The meta-analysis revealed decreased WM volume in the posterior corpus callosum extending to WM in the posterior cingulate cortex. This region was significantly reduced in volume in BD patients in the independent dataset (p = 0.003) but there was no association with clinical variables. We identified a robust WM volume abnormality in BD patients that may represent a trait marker of the disease and used a novel methodology to validate the findings.