No association between FOXP2 rs10447760 and schizophrenia in a replication study of the Chinese Han population. (April 2018)

• Record Type: Journal Article
• Authors: Yin, Jiajun; Jia, Ningren; Liu, Yansong; Jin, Chunhui; Zhang, Fuquan; Yu, Shui; Wang, Jun; Yuan, Jianmin
• Is Part Of: Psychiatric genetics. Volume 28:Number 2(2018:Apr.)
• Publication Date: 2018-04
• Subjects: FOXP2 -- rs10447760 -- schizophrenia; Mental illness -- Genetic aspects -- Periodicals; Periodicals; 616.89042
• DOI: 10.1097/YPG.0000000000000193
• Languages: English
• ISSNs: 0955-8829

Abstract

Abstract : Background: Schizophrenia (SCZ) is a severe and heritable psychiatric disorder, and previous studies have shown that regulation of the forkhead-box P2 gene ( FOXP2 ) may play a role in schizophrenia. Moreover, just a few studies have identified a single nucleotide polymorphism (SNP) rs10447760 within the gene that was a risk variant for SCZ in the Chinese Han population. Methods: To examine whether the variant in the FOXP2 gene contributes toward SCZ susceptibility, we carried out an association analysis of the SNP rs10447760 of the FOXP2 gene in a case–control study (1405 cases, 1137 controls) from China. Results: We identified no association of rs10447760 in the FOXP2 gene with SCZ (all P >0.05). In addition, a meta-analysis indicated that the SNP rs10447760 was not associated with susceptibility to SCZ in Han Chinese populations (pooled odds ratio=1.44, 95% confidence interval: 0.63–3.31, P =0.39). Conclusion: Thus, our results did not support the association between FOXP2 rs10447760 and schizophrenia in a Chinese Han population, and large-scale genetic replication studies with different racial and geographic origins are required in the future.