Characteristic Distribution Pattern of CD30-positive Cytotoxic T Cells Aids Diagnosis of Kikuchi-Fujimoto Disease. Issue 4 (April 2018)

• Record Type: Journal Article
• Authors: Tabata, Tetsuya; Takata, Katsuyoshi; Miyata-Takata, Tomoko; Sato, Yasuharu; Ishizawa, Shin; Kunitomo, Tomoyoshi; Nagakita, Keina; Ohnishi, Nobuhiko; Taniguchi, Kohei; Noujima-Harada, Mai; Maeda, Yoshinobu; Tanimoto, Mitsune; Yoshino, Tadashi
• Is Part Of: Applied immunohistochemistry & molecular morphology. Volume 26:Issue 4(2018)
• Publication Date: 2018-04
• Subjects: histiocytic necrotizing lymphadenitis -- cytotoxic T lymphocytes -- CD30 -- systemic lupus erythematosus; Diagnostic immunohistochemistry -- Periodicals; Immunohistochemistry -- Periodicals; Cells -- Morphology -- Periodicals; Molecular diagnosis -- Periodicals; 616.079
• DOI: 10.1097/PAI.0000000000000411
• Languages: English
• ISSNs: 1541-2016

Abstract

Abstract : Introduction: Histiocytic necrotizing lymphadenitis (or Kikuchi-Fujimoto disease) frequently occurs in Asian young adult females and typically presents as cervical lymphadenopathy with unknown etiology. Although large immunoblasts frequently appear in Kikuchi-Fujimoto disease, the diffuse infiltration of these cells can cause difficulty in establishing a differential diagnosis from lymphoma. In such cases, CD30 immunostaining may be used; however, the extent or distribution pattern of CD30-positive cells in Kikuchi-Fujimoto disease remains largely unknown. Here we investigated the expression of CD30 and its clinicopathologic significance. Materials and Methods: We investigated 30 Kikuchi-Fujimoto disease and 16 control [6, systemic lupus erythematosus (SLE); 10, reactive lymphoid hyperplasia (RLH)] cases. Results: The number of CD30-positive cells in Kikuchi-Fujimoto disease was significantly more than that in SLE and RLH, and majority of these cells were located around necrotic areas. Moreover, double immunohistochemical staining showed these CD30-positive cells to be CD8-positive cytotoxic T cells, suggesting that activated cytotoxic T cells around necrotic areas are a characteristic feature of this disease. Clinicopathologic analysis showed that cases with abundant CD30-positive cells were predominantly female with only mild symptoms and normal laboratory data. Conclusions: In Kikuchi-Fujimoto disease cases, CD30-positive cytotoxic T cells were abundant around necrotic areas; this histologic feature may be helpful to differentiate this disease from SLE and RLH. Abstract : Supplemental Digital Content is available in the text.