Successful Treatment of a Very Late Isolated Relapse in an Adolescent With a PICALM-MLLT10 Positive T-lineage Acute Lymphoblastic Leukemia. Issue 3 (April 2018)

• Record Type: Journal Article
• Authors: Cannata, Emanuela; Samperi, Piera; Cimino, Carla; Marino, Silvia; Sullo, Federica; Mirabile, Elena; Di Cataldo, Andrea; Russo, Giovanna; Lo Nigro, Luca
• Is Part Of: Journal of pediatric hematology/oncology. Volume 40:Issue 3(2018)
• Publication Date: 2018-04
• Subjects: T-lineage -- ALL -- AYA -- relapse -- PICALM-MLLT10 -- therapy; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000000996
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : T-lineage ALL is an aggressive disease that needs to be treated with intensive treatment schedules. A late relapse rarely occurs and a clear choice for second-line treatment is on debate. We report on a young adult with a very late isolated extramedullary relapse of PICALM-MLLT10 positive T-ALL, successfully treated with a chemotherapy-based and radiotherapy-based pediatric protocol. We demonstrate that relapse can occur in T-ALL although a SR-MRD behavior treated with a high-risk protocol; specific molecular diagnostic aberrations, as PICALM-MLLT10, are still conserved at very late relapse; a second-line treatment based on pediatric protocol can be effective. Abstract : Supplemental Digital Content is available in the text.