Body mass index, sitting time, and risk of Parkinson disease. (17th April 2018)

• Record Type: Journal Article
• Authors: Roos, Elin; Grotta, Alessandra; Yang, Fei; Bellocco, Rino; Ye, Weimin; Adami, Hans-Olov; Wirdefeldt, Karin; Trolle Lagerros, Ylva
• Is Part Of: Neurology. Volume 90:Number 16(2018)
• Publication Date: 2018-04-17
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000005328
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : Objective: Causes of Parkinson disease are largely unknown, but recent evidence suggests associations with physical activity and anthropometric measures. Methods: We prospectively analyzed a cohort of 41, 638 Swedish men and women by detailed assessment of lifestyle factors at baseline in 1997. Complete follow-up until 2010 was achieved through linkage to population-based registers. We used multivariable Cox proportional hazards models to estimate hazard ratios with 95% confidence intervals (CIs). Results: We identified 286 incident cases of Parkinson disease during follow-up. Multivariable adjusted hazard ratios were 1.06 (95% CI 0.76–1.47) for sitting time ≥6 vs <6 hours per day; and 1.13 (95% CI 0.60–2.12) for body mass index ≥30 vs <25 kg/m 2 . Results did not differ by sex. Conclusions: No association between prolonged sitting time per day or obesity and risk of Parkinson disease was found.