Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts. Issue 2 (April 2018)

• Record Type: Journal Article
• Authors: Nagele, Peter; Zorumski, Charles F.; Conway, Charles
• Is Part Of: Journal of clinical psychopharmacology. Volume 38:Issue 2(2018)
• Publication Date: 2018-04
• Subjects: nitrous oxide -- major depression -- antidepressant -- rapid onset; Psychopharmacology -- Periodicals; Psychopharmacology -- Periodicals; Psychopharmacologie -- Périodiques; Psychopharmacology; Periodicals; 615.78
• DOI: 10.1097/JCP.0000000000000837
• Languages: English
• ISSNs: 0271-0749

Abstract

Abstract : Abstract: Nitrous oxide (laughing gas) has shown early promise as a rapidly acting antidepressant in patients with treatment-resistant major depression and is currently investigated in several clinical trials. Because nitrous oxide is rarely administered outside operating rooms or dental practices, most psychiatrists are not familiar with how nitrous oxide is administered in a medical setting and what regulations guide its use. The goal of this brief review was to educate psychiatrists about the basic concepts of nitrous oxide administration and pharmacology. Furthermore, common misconceptions about nitrous oxide will be discussed.