Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio). (30th October 2015)

• Record Type: Journal Article
• Authors: Seo, Kyeong-Hwa; Nam, Youn-Hee; Lee, Dae-Young; Ahn, Eun-Mi; Kang, Tong-Ho; Baek, Nam-In
• Is Part Of: Carbohydrate research. Volume 416(2015)
• Page Start: 70
• Page End: 74
• Publication Date: 2015-10-30
• Subjects: Alloxan -- Anti-diabetic -- Magnolia obovata -- Obovatoside -- Pancreatic islet -- Zebrafish; Carbohydrates -- Periodicals; Chemistry, Organic -- Periodicals; Biochemistry -- Periodicals; Carbohydrates -- Periodicals; Chimie organique -- Périodiques; Glucides -- Périodiques; Biochemistry; Carbohydrates; Chemistry, Organic; Periodicals; Electronic journals; 507.78
• DOI: 10.1016/j.carres.2015.07.010
• Languages: English
• ISSNs: 0008-6215

Abstract

Highlights: Three new phenylpropanoid glycosides were isolated from Magnolia obovata fruit. Recovery effects on alloxan-induced islet damage in zebrafish were evaluated. All compounds increased the size of injured pancreatic islets 0.60- to 1.14-fold. The isolated phenylpropanoids increased the glucose absorption ability in zebrafish. Graphical abstract: Abstract: Investigation of phytochemicals from Magnolia obovata fruit led to the isolation of three novel phenylpropanoid glycosides: obovatoside A–C (1 –3 ) and two known phenylpropanoids, syringin (4 ) and pavonisol (5 ). The structures of1 –5 were determined by NMR, HRMS, IR and CD spectroscopic analyses. All compounds were evaluated for their effects on recovery from alloxan-induced pancreatic islet damage in zebrafish. All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds1 and3 –5 significantly increased glucose absorption in zebrafish.