Chiral bicyclic NHC/Ir complexes for catalytic asymmetric transfer hydrogenation of ketones. Issue 84 (7th September 2015)

• Record Type: Journal Article
• Authors: Yoshida, Kazuhiro; Kamimura, Takumi; Kuwabara, Hiroshi; Yanagisawa, Akira
• Is Part Of: Chemical communications. Volume 51:Issue 84(2015)
• Page Start: 15442
• Page End: 15445
• Publication Date: 2015-09-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc05318h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A diverse series of chiral bicyclic NHC/Ir complexes were prepared via a previously developed divergent synthesis of chiral imidazolium salts. Abstract : A diverse series of chiral bicyclic NHC/Ir complexes were prepared via a previously developed divergent synthesis of chiral imidazolium salts. Among the complexes, 8dz was found to be an excellent catalyst precursor for the Ir-catalyzed asymmetric transfer hydrogenation of ketones. The reaction of ketones with8dz proceeded smoothly to give corresponding alcohols with high enantioselectivities (up to 98%) and productivities (TON up to 4500).