Are presynaptic GABA-Cρ2 receptors involved in anti-nociception?. (8th October 2015)

• Record Type: Journal Article
• Authors: Tadavarty, R.; Hwang, J.; Rajput, P.S.; Soja, P.J.; Kumar, U.; Sastry, B.R.
• Is Part Of: Neuroscience letters. Volume 606(2015)
• Page Start: 145
• Page End: 150
• Publication Date: 2015-10-08
• Subjects: GABA-C receptors -- Spinal cord -- Pain -- Anti-nociception -- Substantia gelatinosa -- Dorsal horn; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2015.08.049
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: GABA-C receptors are anti-nociceptive. The ρ2 type are expressed presynaptically in lumbar dorsal horn of the spinal cord. Analgesic effects could be via control of nociceptive input in substantia gelatinosa. Abstract: We investigated the anti-nociceptive effects of GABA-C receptors in the central nervous system. Intracisternal injection of CACA, a GABA-C receptor agonist or isoguvacine, a GABA-A receptor agonist, significantly increased the tail-withdrawal latency. TPMPA, a GABA-C receptor antagonist blocked the effects of CACA but not isoguvacine indicating that GABA-C receptors are involved in regulating pain. Further, double-labelled immunofluorescence studies revealed that GABA-Cρ2 receptors are expressed presynaptically in the spinal dorsal horn, especially, substantia gelatinosa, a region that has been previously implicated in analgesia by regulating nociceptive inflow. These data provide a provenance for future work looking at presynaptic spinal GABA-C receptors in the control of nociception.