Lipoprotein Transport: Greasing the Machines of Outer Membrane Biogenesis: Re‐Examining Lipoprotein Transport Mechanisms Among Diverse Gram‐Negative Bacteria While Exploring New Discoveries and Questions. (7th March 2018)

• Record Type: Journal Article
• Authors: Grabowicz, Marcin
• Is Part Of: BioEssays. Volume 40:Number 4(2018:Apr.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-03-07
• Subjects: envelope stress responses -- lipoprotein transport -- novel antibiotic targets -- outer membrane biogenesis; Molecular biology -- Periodicals; Cytology -- Periodicals; Developmental biology -- Periodicals; 572.8
• DOI: 10.1002/bies.201700187
• Languages: English
• ISSNs: 0265-9247

Abstract

Abstract : The Gram‐negative outer membrane (OM) is a potent permeability barrier against antibiotics, limiting clinical options amid mounting rates of resistance. The Lol transport pathway delivers lipoproteins to the OM. All the OM assembly machines require one or more OM lipoprotein to function, making the Lol pathway central for all aspects of OM biogenesis. The Lol pathways of many medically important species clearly deviate from the Escherichia coli paradigm, perhaps with implications for efforts to develop novel antibiotics. Moreover, recent work reveals the existence of an undiscovered alternate route for bringing lipoproteins to the OM. Here, lipoprotein transport mechanisms, and the quality control systems that underpin them, is re‐examined in context of their diversity. Abstract : All essential outer membrane assembly machines (Bam, Lpt, and Lol) require lipoproteins to function. Hence, the transport mechanisms supplying these lipoproteins are critical for maintaining the integrity of the outer membrane barrier against antibiotics. Lipoprotein transport strategies of diverse Gram‐negative bacteria will be reviewed in the context of recent discoveries.