Flaxseed lignan secoisolariciresinol diglucoside improves insulin sensitivity through upregulation of GLUT4 expression in diet-induced obese mice. (October 2015)

• Record Type: Journal Article
• Authors: Wang, Yanwen; Fofana, Bourlaye; Roy, Moumita; Ghose, Kaushik; Yao, Xing-Hai; Nixon, Marva-Sweeney; Nair, Sandhya; Nyomba, Gregoire B.L.
• Is Part Of: Journal of functional foods. Volume 18:Part A(2016)
• Page Start: 1
• Page End: 9
• Publication Date: 2015-10
• Subjects: Diet-induced obese mice -- Flaxseed SDG -- Fasting blood glucose -- Glucose tolerance -- Insulin tolerance -- GLUT4; Secoisolariciresinol diglucoside (PubChem CID: 9917980); DIO diet-induced obesity -- FBG fasting blood glucose -- FFA free fatty acids -- HFC high-fat diet control -- HOMA-β homeostatic model assessment of β-cell function -- HOMA-IR homeostatic model assessment of insulin resistance -- LFC low-fat diet control -- L10 the high-fat diet supplemented with 10 mg/kg⋅d of flaxseed SDG -- L100 the high-fat diet supplemented with 100 mg/kg⋅d of flaxseed SDG -- L1000 the high-fat diet supplemented with 1000 mg/kg⋅d of flaxseed SDG -- SDG secoisolariciresinol diglucoside -- TAG triacylglycerols -- TC total cholesterol; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2015.06.053
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Flaxseed SDG lignan lowered fasting blood glucose in high-fat diet-induced obese mice. Flaxseed SDG lignan improved oral glucose tolerance and insulin signalling. Flaxseed SDG lignan upregulated GLUT4 protein expression in the skeletal muscle. Flaxseed SDG lignan showed a trend of improving pancreatic β-cell function. Flaxseed SDG lignan is a promising natural agent for insulin resistance and type-2 diabetes. Abstract: The efficacy and mechanism of flaxseed lignan secoisolariciresinol diglucoside (SDG) on glucose hemostasis in obese mice were examined. Male C57BL/6J mice fed on a high-fat diet (60 kcal% fat) for 15 weeks were divided into four groups and treated by oral gavage with 0, 10, 100, or 1000 mg/kg/d of SDG dissolved in water for 6 weeks. Age-matched mice fed with a low-fat diet (10% kcal fat) were used as the normal control. SDG lowered fasting blood glucose, insulin, and free fatty acid levels and improved oral glucose tolerance, insulin response, and homeostatic model assessment-estimated insulin resistance index in mice fed the high-fat diet. Flaxseed SDG also increased GLUT4 expression and tended to increase phosphorylated AKT to total AKT ratio in the muscle tissue. The data demonstrated that flaxseed SDG improved glycaemic control, at least in part, by enhancing insulin signalling and sensitivity in diet-induced obese mice.