Two new alkaloids from Penicillium oxalicum EN-201, an endophytic fungus derived from the marine mangrove plant Rhizophora stylosa. (September 2015)

• Record Type: Journal Article
• Authors: Zhang, Peng; Li, Xiao-Ming; Liu, Hui; Li, Xin; Wang, Bin-Gui
• Is Part Of: Phytochemistry letters. Volume 13(2015:Sep.)
• Page Start: 160
• Page End: 164
• Publication Date: 2015-09
• Subjects: Marine mangrove -- Endophytic fungus -- Penicillium oxalicum -- Alkaloid -- Brine shrimp lethality; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2015.06.009
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Penicillium oxalicum EN-201, an endophyte of mangrove Rhizophora stylosa, was studied. Two new alkaloids, penioxamide A (1 ) and 18-hydroxydecaturin B (2 ), were identified. Compounds1 and2 showed potent brine shrimp lethality against Artemia salina. Abstract: Two new alkaloids including a new prenylated indole derivative possessing a piperidine moiety, penioxamide A (1 ), and a new decaturin analogue, 18-hydroxydecaturin B (2 ), were isolated and identified from Penicillium oxalicum EN-201, an endophytic fungus obtained from the inner tissue of the fresh leaves of marine mangrove plant Rhizophora stylosa . Their structures and absolute configurations were elucidated on the basis of the spectral data and CD analysis. Compound1 bears the rare anti relative configuration in the bicyclo[2.2.2]diazaoctane ring, while compound2 has a pyridinyl- α -pyrone substructure which is rare among natural products. Compounds1 and2 showed potent brine shrimp lethality with LD50 values of 5.6 and 2.3 μM, respectively.