Monoterpenoids and Triterpenoids from Pterocephalus hookeri with NF-κB inhibitory activity. (September 2015)

• Record Type: Journal Article
• Authors: Wu, Yingchun; Lu, Jing; Lu, XiaoQiuYu; Li, Ran; Guo, Jing; Guo, Fujiang; Li, Yiming
• Is Part Of: Phytochemistry letters. Volume 13(2015:Sep.)
• Page Start: 30
• Page End: 34
• Publication Date: 2015-09
• Subjects: Pterocephalus hookeri -- Monoterpenoids -- Triterpenoids -- Inhibition of NF-κB; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2015.05.012
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new rare arranged bis-iridoids, one novel triterpenoid isolated from Pterocephlus hookeri . Two known triterpenoids isolated from P. hookeri first time. Compounds1 –2 showed obvious activity in inhibiting NF-κB. Abstract: In this study, we isolated two new monoterpenoids hookerinoids A and B (1 and2 ; rare arranged nonglycosidic bis-iridoids) and hookerinoid C (3 ; a novel norursane-type triterpenoid) in addition to two known compounds, 11, 12-epoxy-2, 6-dihydroxy-24-norursa-1, 4-dien-3-on-2-on-(28 → 13)-olide (4 ) and rivularicin (5 ), from Pterocephalus hookeri . The structures of1–3 were established using one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionisation mass spectrometry. All compounds were isolated from this plant for the first time. Bis-iridoids isolated from P. hookeri possessed secoiridoid/iridoid subtype skeletons. Therefore, bis-iridoids can be considered chemotaxonomic markers of P. hookeri . The origins of the new compounds (1–3 ) were postulated and their inhibitory activities on a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway were assayed;1 and2 showed obvious activity in inhibiting NF-κB.